Introduce
Genetic Variants Screening for solid tumors diagnostics
NGeneBio’s ONCOaccuPanel™ is the next generation of sequencing (NGS) To establish diagnostic and treatment strategies and predict prognosis for patients with solid cancer. In vitro diagnostic medical device.
ONCOaccuPanel ™ is an Essential Gene for Health Notification by the Ministry of Health and Welfare It consists of 328 genes, including 14, that are specific to cancer patients in Korea. Analytical automation software is also provided for convenience in the field You can increase it.
Working Process
Specification
| ONCOaccuPanel™ | |
|---|---|
| Useful | Solid tumor |
| Technique | NGS (Next Generation Sequencing) |
| Platforms | Illumina, MiSeq, MiSeqDx, NextSeq 500/550. NextSeq 500/550 Dx |
| Target enrichments | Capture based Hybridization |
| Sample Source | FFPOE, blood |
| Sample type | DNA, RNA |
| Quantity | 96 samples (MiSeq system), 768 samples (NextSeq system) |
| Analysis solution | NGeneAnalySys™ |
| Target genes | Total 328 genes |
| Target size | 1.1 MB |
| Bariants type | SNV, INDEL, CNV, SV, MSI, (TMB) |
| Turn around time | 1.5 days |
Performance
| SNV, Indel mutation | Translocation | CNV | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target coverage | TP | TN/FN | TP | TN | TP | TN | ||||||
| 234 | 2895/5 | 3 | 295 | 89 | 824 | |||||||
| NextSeq results | TP | TN | TP | TN | TP | TN | TP | TN | TP | TN | TP | TN |
| 23 | 1 | 5 | 28 | 3 | 0 | 0 | 29 | 86 | 3 | 3 | 821 | |
| 3 | 94 | 5 | ||||||||||
| Sensitivity | 99.6% | 100% | 96.6% | |||||||||
| Specificity | 100% | 100% | 96.6% | |||||||||
Sensitivity = (next231+sanger2)/(miseq 232+sanger2) ▸ TP/(TP+FN) = 233/234 = 99.57%
Speccificity = (next2890+sanger4)/(miseq 2896+sanger4) ▸ TP/(TP+FN) = 2894/2900 = 99.79%
Information
| Cat no. | Products | No. of samples |
|---|---|---|
NGB121UWW |
ONCOaccuPanel™ (Include library prep and enrichment reagents) |
96 samples (MiSeq) 768 samples (NextSeq) |
